Structure of PDB 5v5x Chain C

Receptor sequence

>5v5xC (length=415) Species: 10090 (Mus musculus)

PVFSQDVYRVRLPEDLPPGTTVLRLKAAEFTYSFLGVANKAQFSLDPITG
DIVTRQSLDFEEVEQYTIDVEAKDRGSLSSQCKVIIEVLDENDNRPEIII
TSLSDQISEDSPSGTVVALFKVRDRDSGENAEVMCSLSGNNPFKIHSSSN
NYYKLVTDSILDREQTPGYNVTITATDRGKPPLSSSTTITLNVADVNDNA
PVFQQQAYLINVAENNQPGTSITQVKAWDPDVGSNGLVSYSIIASDLEPK
ALSSFVSVNQDSGVVYAQRAFDHEQIRSFQLTLQARDQGSPALSANVSMR
VLVDDRNDNAPRVLYPTLEPDGSALFDMVPRAAEPGYLVTKVVAVDADSG
HNAWLSYHVLQASDPGLFSLGLRTGEVRTARALSDKDAARQRLLVAVRDG
GQPPLSATATLLLVF

3D structure

• PDB: 5v5x Protocadherin cis-dimer architecture and recognition unit diversity.
• Chain: C
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	C	E223 D276 E278 D310	E14 D59 E61 D93
BS02	CA	C	E223 E278 D307 E308 D310 D343	E14 E61 D90 E91 D93 D126
BS03	CA	C	N309 N311 D341 D343 N347 D394	N92 N94 D124 D126 N130 D177
BS04	CA	C	E326 D379 E381 D415	E109 D162 E164 D198
BS05	CA	C	E326 E381 D412 V413 D415 D448	E109 E164 D195 V196 D198 D231
BS06	CA	C	N414 N416 D446 D448 N452 D504	N197 N199 D229 D231 N235 D287
BS07	CA	C	E431 D489 E491 D525	E214 D272 E274 D308
BS08	CA	C	E431 E491 D522 R523 D525 D565	E214 E274 D305 R306 D308 D348
BS09	CA	C	N524 N526 D563 D565 N569 D616	N307 N309 D346 D348 N352 D399
BS10	MAN	C	R615 S623	R398 S406
BS11	MAN	C	G228 T230 R233 D268	G19 T21 R24 D51

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5v5x, PDBe:5v5x, PDBj:5v5x
• PDBsum: 5v5x
• PubMed: 29087338
• UniProt: Q91XX3