Structure of PDB 5v3o Chain C

Receptor sequence
>5v3oC (length=363) Species: 9606 (Homo sapiens) [Search protein sequence]
INFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQT
LPLQLFHPQEVSMVRNLIQKDRTFAVLAYSAQFGTTAEIYAYREEQDFGI
EIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESL
NKCQIFPSSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQL
REWDDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIM
NKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKA
CNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFW
GLTRSALLPTIPD
3D structure
PDB5v3o A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8W7 C N351 P352 E377 H378 S379 W380 W386 W400 F402 N286 P287 E312 H313 S314 W315 W321 W335 F337 PDBbind-CN: -logKd/Ki=7.22,IC50=60nM
BS02 ZN C C323 C326 C391 C394 C258 C261 C326 C329
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0034766 negative regulation of monoatomic ion transmembrane transport
GO:0035641 locomotory exploration behavior
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902607 negative regulation of large conductance calcium-activated potassium channel activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5v3o, PDBe:5v3o, PDBj:5v3o
PDBsum5v3o
PubMed28425720
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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