Structure of PDB 5uyx Chain C

Receptor sequence
>5uyxC (length=474) Species: 9606 (Homo sapiens) [Search protein sequence]
LEALKSHIMAAKAVANTMRTSLGPNGLNDGATILSMMDVDHQIAKLMVEL
SKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVA
IEHLDKISDSVLVDIKDTEPLIQTAKSCHRQMAEIAVNAVLTVADMERRD
VDFELIKVEGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEP
PKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFD
DEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAG
LVQEISFGTTKDKMLVIEQAVTIFIRGGNKMIIEEAKRSLHDALCVIRNL
IRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMAL
SENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIG
KKQQISLATQMVRMILKIDDIRKP
3D structure
PDB5uyx Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy.
ChainC
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D73 T106 T107 D404
Catalytic site (residue number reindexed from 1) D29 T62 T63 D342
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C L52 G53 G105 T107 G422 C493 E508 L22 G23 G61 T63 G360 C431 E446
Gene Ontology
Molecular Function
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0031681 G-protein beta-subunit binding
GO:0044183 protein folding chaperone
GO:0048027 mRNA 5'-UTR binding
GO:0048487 beta-tubulin binding
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0009615 response to virus
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0061077 chaperone-mediated protein folding
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0044297 cell body
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5uyx, PDBe:5uyx, PDBj:5uyx
PDBsum5uyx
PubMed28623285
UniProtP48643|TCPE_HUMAN T-complex protein 1 subunit epsilon (Gene Name=CCT5)

[Back to BioLiP]