Structure of PDB 5uwi Chain C

Receptor sequence
>5uwiC (length=1001) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GSMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAW
QKADQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMI
ISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSS
VNVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCF
QVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDT
RAITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLK
ATYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLI
QLSKIEERELFKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENM
VRPEKESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSW
HNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLGLCEQKRGKDNKAVVA
SDIMYVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMACDTFIKI
VQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIII
SEERSVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANI
IKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATK
TPKVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNN
VPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINKDFTEY
PEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEV
NGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGF
SKQALLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYLANMLSNA
FPHLTSEQIASFLSALTKQCKDLVVFKGTLRDFLVQIKEVGGDPTDYLFA
E
3D structure
PDB5uwi Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
ChainC
Resolution2.143 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C K525 V529 L536 C539 K545 K548 H569 F572 T575 K579 F583 R616 K473 V477 L484 C487 K493 K496 H517 F520 T523 K527 F531 R564
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uwi, PDBe:5uwi, PDBj:5uwi
PDBsum5uwi
PubMed28282025
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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