Structure of PDB 5uwf Chain C

Receptor sequence
>5uwfC (length=323) Species: 9606 (Homo sapiens) [Search protein sequence]
SMASICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVH
RSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNH
TLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHH
FSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQL
EEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAE
FWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQIL
PPTEPLLKACRDNLSQWEKVIRG
3D structure
PDB5uwf Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.
ChainC
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8Q7 C Y524 H525 L675 V678 I692 Y693 F696 I711 M713 Q726 F729 Y79 H80 L230 V233 I247 Y248 F251 I266 M268 Q281 F284 MOAD: ic50=0.059uM
PDBbind-CN: -logKd/Ki=7.23,IC50=0.059uM
BindingDB: IC50=59nM
BS02 ZN C H529 H563 D564 D674 H84 H118 D119 D229
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5uwf, PDBe:5uwf, PDBj:5uwf
PDBsum5uwf
PubMed28406621
UniProtQ9Y233|PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Gene Name=PDE10A)

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