Structure of PDB 5uw6 Chain C

Receptor sequence
>5uw6C (length=701) Species: 39387 (Gypsophila vaccaria) [Search protein sequence]
GFSKPLHYPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEK
LANSVLEECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQN
VFQMQDDLDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTE
WVTIKILKTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPVNQEARY
HFLGTDQSEDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVY
CLDLTKLPNGLESFAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKK
LVRVDLNNPSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIR
DLESGALQHRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKN
DPTQLKIFRESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDG
SHPCEMHGYGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEW
HKAGFRDKKQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACI
NQRPDLFGCAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKY
SPIHNVRRPWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVL
CTSLEDSPQKNPIIARIQRKAAHYGRATMTQIAEVADRYGFMAKALEAPW
I
3D structure
PDB5uw6 Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.
ChainC
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y481 S562 D653 H695
Catalytic site (residue number reindexed from 1) Y459 S540 D631 H673
Enzyme Commision number 3.4.21.-
3.4.21.26: prolyl oligopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R81 F95 A102 N104 F492 S493 A494 S495 T700 Q703 R77 F91 A98 N100 F470 S471 A472 S473 T678 Q681
BS02 ZPR C H239 C259 Y481 F484 S562 N563 W603 R655 H223 C243 Y459 F462 S540 N541 W581 R633
BS03 CA C E61 E64 E57 E60
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
GO:0070012 oligopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uw6, PDBe:5uw6, PDBj:5uw6
PDBsum5uw6
PubMed28584123
UniProtR4P353

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