Structure of PDB 5uvw Chain C

Receptor sequence
>5uvwC (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
KRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMD
MGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKL
FLQKINELP
3D structure
PDB5uvw BRD4_Bromodomain1-A1376855
ChainC
Resolution2.14 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8NG C W81 P82 Q85 V87 D88 K91 L92 N140 I146 W25 P26 Q29 V31 D32 K35 L36 N84 I90 BindingDB: IC50=20nM,Ki=1.5nM,Kd=<10.0nM,EC50=20nM
External links
PDB RCSB:5uvw, PDBe:5uvw, PDBj:5uvw
PDBsum5uvw
PubMed
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]