Structure of PDB 5umb Chain C

Receptor sequence
>5umbC (length=377) Species: 5843 (Plasmodium falciparum NF54) [Search protein sequence]
EGPVIGIDLGTTYSCVGVFKNGRVEILNNELGNRITPSYVSFVDGERKVG
EAAKLEATLHPTQTVFDVKRLIGRKFDDQEVVKDRSLLPYEIVNNQGKPN
IKVQIKDKDTTFAPEQISAMVLEKMKEIAQSFLGKPVKNAVVTVPAYFND
AQRQATKDAGTIAGLNIVRIINEPTAAALAYGLDKEETSILVYDLGGGTF
DVSILVIDNGVFEVYATAGNTHLGGEDFDQRVMDYFIKMFKKKNNIDLRT
DKRAIQKLRKEVEIAKRNLSVVHSTQIEIEDIVEGHNFSETLTRAKFEEL
NDDLFRETLEPVKKVLDDAKYEKSKIDEIVLVGGSTRIPKIQQIIKEFFN
GKEPNRGINPDEAVAYGAAIQAGIILG
3D structure
PDB5umb Repurposing drugs to target the malaria parasite unfolding protein response.
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C G36 T37 T38 Y39 G223 G224 G252 E290 K293 R294 S297 G361 R364 G10 T11 T12 Y13 G196 G197 G225 E263 K266 R267 S270 G334 R337
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:5umb, PDBe:5umb, PDBj:5umb
PDBsum5umb
PubMed29985421
UniProtQ05866|BIP_PLAFO Endoplasmic reticulum chaperone BIP (Gene Name=BIP)

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