Structure of PDB 5ui1 Chain C

Receptor sequence
>5ui1C (length=317) Species: 9606 (Homo sapiens) [Search protein sequence]
YSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLST
LVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDR
GSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTA
QMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQP
PDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIR
SHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQ
FTAVPHPNVKPMAYANT
3D structure
PDB5ui1 Crystal Structure Human PP5C in Complex with an Inhibitor
ChainC
Resolution1.96 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D242 H244 D271 D274 R275 N303 H304 H352 R400 H427
Catalytic site (residue number reindexed from 1) D67 H69 D96 D99 R100 N128 H129 H177 R225 H252
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN C D242 H244 D271 H427 D67 H69 D96 H252
BS02 MN C D271 N303 H352 H427 D96 N128 H177 H252
BS03 8D4 C D271 R275 N303 H304 M309 Y313 H427 Y451 D96 R100 N128 H129 M134 Y138 H252 Y276
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5ui1, PDBe:5ui1, PDBj:5ui1
PDBsum5ui1
PubMed
UniProtP53041|PPP5_HUMAN Serine/threonine-protein phosphatase 5 (Gene Name=PPP5C)

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