Structure of PDB 5ufi Chain C

Receptor sequence
>5ufiC (length=192) Species: 9606 (Homo sapiens) [Search protein sequence]
LDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKF
RAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQ
FTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIP
KDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFARPQI
3D structure
PDB5ufi A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation.
ChainC
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8B1 C F89 P97 V102 Q114 C115 E116 F117 F164 M177 Y181 F30 P38 V43 Q55 C56 E57 F58 F105 M118 Y122 BindingDB: IC50=21nM
External links
PDB RCSB:5ufi, PDBe:5ufi, PDBj:5ufi
PDBsum5ufi
PubMed29074978
UniProtQ96GG9|DCNL1_HUMAN DCN1-like protein 1 (Gene Name=DCUN1D1)

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