Structure of PDB 5uch Chain C

Receptor sequence
>5uchC (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
GHMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNAS
DALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADL
INNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITK
HNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRV
KEVVKKHSQFIGYPITLYL
3D structure
PDB5uch Structure-guided design of an Hsp90 beta N-terminal isoform-selective inhibitor.
ChainC
Resolution2.654 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 871 C L43 N46 D49 A50 D88 I91 G92 M93 F133 T179 L45 N48 D51 A52 D90 I93 G94 M95 F135 T181 BindingDB: Kd=970nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:5uch, PDBe:5uch, PDBj:5uch
PDBsum5uch
PubMed29382832
UniProtP08238|HS90B_HUMAN Heat shock protein HSP 90-beta (Gene Name=HSP90AB1)

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