Structure of PDB 5th9 Chain C

Receptor sequence
>5th9C (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
DRQLAEEYLYRYGYTRGPALLLLQKQLSLPETGELDSATLKAMRTPRCGV
PDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAV
TPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGD
AHFDDDELWSLGKGQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFT
EGPPLHKDDVNGIRHLY
3D structure
PDB5th9 Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
ChainC
Resolution2.999 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H401 E402 H405 H411
Catalytic site (residue number reindexed from 1) H175 E176 H179 H185
Enzyme Commision number 3.4.24.35: gelatinase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C99 H401 H405 H411 C48 H175 H179 H185
BS02 ZN C H175 D177 H190 H203 H124 D126 H139 H152
BS03 CA C D165 G197 Q199 D201 D114 G146 Q148 D150
BS04 CA C D182 G183 D185 L187 D205 E208 D131 G132 D134 L136 D154 E157
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5th9, PDBe:5th9, PDBj:5th9
PDBsum5th9
PubMed28235803
UniProtP14780|MMP9_HUMAN Matrix metalloproteinase-9 (Gene Name=MMP9)

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