Structure of PDB 5tf6 Chain C

Receptor sequence

>5tf6C (length=366) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

MLTRNRELTTVLVKNLPKSYNQNKVYKYFKHCGPIIHVDVADSLKKNFRF
ARIEFARYDGALAAITKTHKVVGQNEIIVSHLTECTLWMTNFPPSYTQRN
IRDLLQDINVVALSIRLPSLRFNTSRRFAYIDVTSKEDARYCVEKLNGLK
IEGYTLVTKVSNPLEKSKRTDSATLEGREIMIRNLSTELLDENLLRESFE
GFGSIEKINIPAGQKEHSFNNCCAFMVFENKDSAERALQMNRSLLGNREI
SVSLADKKPFLERNEVKRLLASRNSKELETLICLFPLSDKVSPSLICQFL
QEEIHINEKDIRKILLVSDFNGAIIIFRDSKFAAKMLMILNGSQFQGKVI
RSGTINDMKRYYNNQQ

3D structure

PDB

5tf6 Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	C	K62 H63 Y90 K102	K30 H31 Y58 K70	PDBbind-CN: Kd=2.9nM
BS02	rna	C	M33 T35 R36 R38 W120 T122 N123 R148 P150 S151 F154 R158 R159 F160 Y162 S193 N194 P195 K198 R201 T202 D203 T206 E211 M213 R215 N216 K239 N241 P243 Q246 F251 N252 N253 C255 F257 S283 D288 K289 K290 P291 F292 R295 K299	M1 T3 R4 R6 W88 T90 N91 R116 P118 S119 F122 R126 R127 F128 Y130 S161 N162 P163 K166 R169 T170 D171 T174 E179 M181 R183 N184 K207 N209 P211 Q214 F219 N220 N221 C223 F225 S251 D256 K257 K258 P259 F260 R263 K267	PDBbind-CN: Kd=2.9nM

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

View graph for
Molecular Function

External links

PDB	RCSB:5tf6, PDBe:5tf6, PDBj:5tf6
PDBsum	5tf6
PubMed	28045380
UniProt	P49960\|PRP24_YEAST U4/U6 snRNA-associated-splicing factor PRP24 (Gene Name=PRP24)

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