Structure of PDB 5szl Chain C

Receptor sequence

>5szlC (length=418) Species: 10090 (Mus musculus)

NIRYSVPEETDKGSFVGSIAKDLGLETRELMERGIRIVSRGRSQLFSLNP
RSGSLVTAGRIDREELCAQSTPCVVSFNILMEDEMKLLPIEVEIIDINDN
TPQFQLEELELKMSEITTPGTRIPLPLGQDLDVGINSLQSYQLSANPHFS
LDVQQGPEGPQQPEMVLQRPLDREKDAVHYLVLTASDGGSPIHSGTLQIH
VQVVDVNDNPPAFTKAEYHVSVPENVPLGTRLLKVNATDPDEGANGRVTY
SFHKVDHSVVRKFQLDAYTGELSNKEPLDFEEYKVYPMEIQAQDGAGLMA
RAKVLVTVLDVNDNAPEVGITSVTNTVPENFPPGTTIALISVHDQDADNN
GHITCSIPGNLPFKLEKLVDNYYRLVTERTLDREQSSRHNITITATDQGT
PPLSTQAHISLLVTDIND

3D structure

• PDB: 5szl gamma-Protocadherin structural diversity and functional implications.
• Chain: C
• Resolution: 4.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	C	T197 Q199	T196 Q198
BS02	CA	C	N208 N210 D240 D242 N246 D295	N207 N209 D239 D241 N245 D294
BS03	CA	C	E116 E175 D206 V207 D209 D242	E115 E174 D205 V206 D208 D241
BS04	CA	C	E116 D173 E175 D209	E115 D172 E174 D208
BS05	CA	C	E9 E65 D97 I98 D100 D133	E8 E64 D96 I97 D99 D132
BS06	CA	C	N99 N101 D131 D133 N137 D188	N98 N100 D130 D132 N136 D187
BS07	CA	C	E9 E10 D63 E65 D100	E8 E9 D62 E64 D99
BS08	CA	C	E225 E282 D311 V312 D314 D347	E224 E281 D310 V311 D313 D346
BS09	CA	C	E225 D280 E282 D314	E224 D279 E281 D313
BS10	CA	C	N313 N315 D345 D347 N351 D398	N312 N314 D344 D346 N350 D397

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5szl, PDBe:5szl, PDBj:5szl
• PDBsum: 5szl
• PubMed: 27782885
• UniProt: Q91XZ0