Structure of PDB 5sc9 Chain C

Receptor sequence

>5sc9C (length=417) Species: 9606 (Homo sapiens)

QQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKE
MIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALD
TKGPPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHG
IKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMI
GRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGE
TAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAI
GAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVH
LCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG
WRPGSGYTNIMRVLSIS

3D structure

• PDB: 5sc9 Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.
• Chain: C
• Resolution: 1.685 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.40: pyruvate kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FBP	C	L443 T444 T445 T446 S449 W494 R501 G526 R528 P529 G530 S531 Y533 T534	L317 T318 T319 T320 S323 W368 R375 G400 R402 P403 G404 S405 Y407 T408
BS02	OXL	C	K282 E284 A305 G307 D308 T340	K156 E158 A179 G181 D182 T214
BS03	I7K	C	T62 P65 R85 N87 H90 Y95 S374 G375 A378	T37 P40 R60 N62 H65 Y70 S248 G249 A252
BS04	MG	C	E284 D308	E158 D182
BS05	MG	C	N87 S89 D125 T126	N62 S64 D100 T101

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003824 catalytic activity
• GO:0004743 pyruvate kinase activity
• GO:0030955 potassium ion binding

Biological Process

• GO:0006096 glycolytic process

External links

• PDB: RCSB:5sc9, PDBe:5sc9, PDBj:5sc9
• PDBsum: 5sc9
• PubMed: 35290845
• UniProt: P30613|KPYR_HUMAN Pyruvate kinase PKLR (Gene Name=PKLR)