Structure of PDB 5q15 Chain C

Receptor sequence
>5q15C (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
ELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEAFSAEENFLILTEMATN
HVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSG
HSDLLEARIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSP
DRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTF
NHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
3D structure
PDB5q15 D3R Grand Challenge 2: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies.
ChainC
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C V303 K307 H317 I321 L324 K325 P467 L468 E471 I472 V56 K60 H70 I74 L77 K78 P220 L221 E224 I225
BS02 9MP C I277 N287 L291 M294 H298 M332 F333 S336 F340 I356 S359 I361 M369 Y373 W458 I30 N40 L44 M47 H51 M85 F86 S89 F93 I109 S112 I114 M122 Y126 W211 BindingDB: IC50=8.900000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5q15, PDBe:5q15, PDBj:5q15
PDBsum5q15
PubMed29204945
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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