Structure of PDB 5o76 Chain C

Receptor sequence
>5o76C (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]
PGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRT
ILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQP
RRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEK
TIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRL
FQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSC
TRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNP
DLTGLCEPTPQDHIKVTQEQFELYCEMGSTFQLCKICAENDKDVKIEPCG
HLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPF
3D structure
PDB5o76 A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
ChainC
Resolution2.473 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C Y274 R294 S296 T298 Y307 L315 Q316 T317 E334 F336 Y227 R247 S249 T251 Y260 L268 Q269 T270 E287 F289
BS02 ZN C C381 C384 C401 C404 C334 C337 C354 C357
BS03 ZN C C396 H398 C416 C349 H351 C369
BS04 CA C D229 T231 N233 Y235 E240 D182 T184 N186 Y188 E193
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:5o76, PDBe:5o76, PDBj:5o76
PDBsum5o76
PubMed29053960
UniProtP22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL (Gene Name=CBL)

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