Structure of PDB 5o5k Chain C

Receptor sequence
>5o5kC (length=216) Species: 1299331 (Mycobacterium intracellulare 1956) [Search protein sequence]
AVMEAEYERSEALLANMLPGSIAERLKSSSRSVIADKYDEVSVLFADIVG
FTERASTTTPADLVRFLNRLYGAFDELVDKHGLEKIKVSGDSYMVVSGVP
RARPDHAFALADFALDMANVAAALKDPHGDPVPLRMGMACGPVVAGVVGS
RRFFYDVWGDAVNVASRMESTDSVGRIQVPEAMYERLKNEFVLQERGRIE
VKGKGVMRTWYLIGRK
3D structure
PDB5o5k Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation.
ChainC
Resolution3.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D256 I257 D300 R376 K411
Catalytic site (residue number reindexed from 1) D47 I48 D91 R167 K202
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ONM C M303 D365 V366 G368 N372 M94 D156 V157 G159 N163
BS02 ONM C D256 I257 G259 F260 T261 L272 G299 D300 R344 D47 I48 G50 F51 T52 L63 G90 D91 R135
BS03 MN C D256 I257 D300 D47 I48 D91
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5o5k, PDBe:5o5k, PDBj:5o5k
PDBsum5o5k
PubMed29087332
UniProtX8CHM4

[Back to BioLiP]