Structure of PDB 5nzn Chain C

Receptor sequence
>5nznC (length=387) Species: 11309 (unidentified influenza virus) [Search protein sequence]
SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRT
FFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSA
SACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESEC
ACVNGSCFTVMTDGPNNGQASYKIFRIEKGKIVKSVEMNAPNYYYEECSC
YPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDK
TGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWT
GTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRP
KENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTID
3D structure
PDB5nzn Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus.
ChainC
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C D294 G298 D324 G342 N344 D213 G217 D243 G261 N263
BS02 CA C D376 N378 D384 N386 D295 N297 D303 N305
BS03 G39 C R118 E119 D151 R152 W179 E277 R293 R368 Y402 R37 E38 D70 R71 W98 E196 R212 R287 Y321 MOAD: Ki=220000nM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nzn, PDBe:5nzn, PDBj:5nzn
PDBsum5nzn
PubMed29933553
UniProtC3W6G3

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