Structure of PDB 5nsq Chain C

Receptor sequence
>5nsqC (length=518) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
LPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTH
KQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVV
VGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPI
AAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVA
TSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGY
GGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPA
DYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRN
DDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLT
GAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEF
KSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNS
NGATGFGPALLTEYFRKL
3D structure
PDB5nsq Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation inTrypanosoma brucei.
ChainC
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K301 R375
Catalytic site (residue number reindexed from 1) K298 R372
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 MN C K289 D294 D312 E373 K286 D291 D309 E370
BS02 MN C D294 D371 E373 D291 D368 E370
BS03 BB2 C D294 D371 E373 G404 A405 D291 D368 E370 G401 A402
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5nsq, PDBe:5nsq, PDBj:5nsq
PDBsum5nsq
PubMed28815215
UniProtQ385B0

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