Structure of PDB 5nfj Chain C

Receptor sequence
>5nfjC (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
MQPLVFDMAYENYMKRKELQNTVSQLLESEGWNRRNVDPFHIYFCNLKID
GALHRELVKRYQEKWDKLLLTSTEKSHVDLFPKDSIIYLTADSPNVMTTF
RHDKVYVIGSFVDKSMQPGTSLAKAKRLNLATECLPLDKYLQWEIGNKNL
TLDQMIRILLCLKNNGNWQEALQFVPKR
3D structure
PDB5nfj Crystal structure of the methyltransferase subunit of human mitochondrial Ribonuclease P (MRPP1) bound to S-adenosyl-methionine (SAM)
ChainC
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.218: tRNA (adenine(9)-N(1))-methyltransferase.
2.1.1.221: tRNA (guanine(9)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM C L290 T291 A292 I309 G310 F312 D314 Q318 T321 S322 C335 L336 K349 N350 L351 M356 L89 T90 A91 I108 G109 F111 D113 Q117 T120 S121 C134 L135 K148 N149 L150 M155
Gene Ontology
Biological Process
GO:0008033 tRNA processing
Cellular Component
GO:0005739 mitochondrion

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Biological Process
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Cellular Component
External links
PDB RCSB:5nfj, PDBe:5nfj, PDBj:5nfj
PDBsum5nfj
PubMed
UniProtQ7L0Y3|TM10C_HUMAN tRNA methyltransferase 10 homolog C (Gene Name=TRMT10C)

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