Structure of PDB 5n5s Chain C

Receptor sequence
>5n5sC (length=481) Species: 3218 (Physcomitrium patens) [Search protein sequence]
VTPKKYNIFLASKPVDGDRKWLDVTNKYTNDVAAKVPQATHKDIDDAIDA
AVAAAPAMAAMGAYERKAVLEKVVAELKNRFEEIAQTLTMESGKPIKDAR
GEVTRTIDTFQVAAEESVRIYGEHIPLDISARNKGLQGIVKKFPIGPVSM
VSPWNFPLNLVAHKVAPAIAVGCPFVLKPASRTPLSALILGEILHKIEEL
PLGAFSILPVSREDADMFTVDERFKLLTFTGSGPIGWDMKARAGKKKVVM
ELGGNAPCIVDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYD
EVKEGFVAAVKKLKMGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGK
LLTGGNRKGAFIEPTVIEDVPIEANARKEEIFGPVVLLYKYSDFKEAVKE
CNNTHYGLQSGIFTKDLNKAFYAFEHMEVGGVILNDSPALRVDSQPYGGL
KDSGIQREGVKYAMDDMLETKVLVMRNVGTL
3D structure
PDB5n5s The ALDH21 gene found in lower plants and some vascular plants codes for a NADP(+) -dependent succinic semialdehyde dehydrogenase.
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N171 K194 E267 C302 E396 E474
Catalytic site (residue number reindexed from 1) N155 K178 E251 C286 E380 E458
Enzyme Commision number 1.2.1.9: glyceraldehyde-3-phosphate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C V167 S168 P169 W170 N171 L176 K194 A196 S197 R228 T246 G247 S248 I251 E267 L268 C302 E396 F398 Y463 V151 S152 P153 W154 N155 L160 K178 A180 S181 R212 T230 G231 S232 I235 E251 L252 C286 E380 F382 Y447 MOAD: Kd=31uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008911 lactaldehyde dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

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Molecular Function
External links
PDB RCSB:5n5s, PDBe:5n5s, PDBj:5n5s
PDBsum5n5s
PubMed28749584
UniProtA9SS48

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