Structure of PDB 5n55 Chain C

Receptor sequence
>5n55C (length=228) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
EYPTVEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLL
IDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRKAGVA
TYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTD
NLVVYVPSANVLYGGCAVLALSRTSAGNVADADLAEWPTSVERIQKHYPE
AEVVIPGHGLPGGLDLLQHTANVVTAHK
3D structure
PDB5n55 Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition.
ChainC
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H114 H116 D118 H179 C198 L201 N210 H240
Catalytic site (residue number reindexed from 1) H82 H84 D86 H147 C166 L169 N178 H208
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H114 H116 H179 H82 H84 H147
BS02 8NN C F62 Y67 P68 W87 H116 D117 D118 R205 G209 N210 H240 F30 Y35 P36 W55 H84 D85 D86 R173 G177 N178 H208 MOAD: Kd=1.03uM
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