Structure of PDB 5myv Chain C

Receptor sequence
>5myvC (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
YHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQH
YTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFE
VLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKP
ENILMCVDDAYVRRMAAEATLLVNPLDPRNADKIRVKIADLGNACWVHKH
FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGE
DYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWS
LFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS
3D structure
PDB5myv Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ChainC
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D225
Catalytic site (residue number reindexed from 1) D147
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W4A C L180 G181 Y239 L102 G103 Y161
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5myv, PDBe:5myv, PDBj:5myv
PDBsum5myv
PubMed28135068
UniProtP78362|SRPK2_HUMAN SRSF protein kinase 2 (Gene Name=SRPK2)

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