Structure of PDB 5mym Chain C

Receptor sequence
>5mymC (length=205) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SLPRGRRTARPSGDDRELAILATAENLLEDRPLADISVDDLAKGAGISRP
TFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINV
FFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDR
GAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVT
SIYGE
3D structure
PDB5mym Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.
ChainC
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HYV C G106 I107 F110 F114 G124 Q125 R128 W138 M142 T149 N176 N179 E180 L183 F184 W207 G97 I98 F101 F105 G115 Q116 R119 W129 M133 T140 N167 N170 E171 L174 F175 W198 MOAD: ic50=3.9uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:5mym, PDBe:5mym, PDBj:5mym
PDBsum5mym
PubMed29018348
UniProtP9WMC1|ETHR_MYCTU HTH-type transcriptional regulator EthR (Gene Name=ethR)

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