Structure of PDB 5msv Chain C

Receptor sequence

>5msvC (length=514) Species: 679197 (Segniliparus rugosus ATCC BAA-974)

RPVIETVQRAAAALLGVDPEAHFSDLGGDSLSALTYSNFLHEIFQVEVPV
SVIVSAANNLRSVAAHIEKERSSDRPTFASVHGAGATTIRASDLKLEKFL
DAQTLAAAPSLPRPASEVRTVLLTGSNGWLGRFLALAWLERLVPQGGKVV
VIVRGKDDKAAKARLDSVFESGDPALLAHYEDLADKGLEVLAGDFSDADL
GLRKADWDRLADEVDLIVHSGALVNHVLPYSQLFGPNVVGTAEVAKLALT
KRLKPVTYLSTVAVAVGVEPSAFEEDGDIRDVSAVRSIDEGYANGYGNSK
WAGEVLLREAYEHAGLPVRVFRSDMILAHRKYTGQLNVPDQFTRLILSLL
ATGIAPKSFYQLDATGGRQRAHYDGIPVDFTAEAITTLGLAGSDGYHSFD
VFNPHHDGVGLDEFVDWLVEAGHPISRVDDYAEWLSRFETSLRGLPEAQR
QHSVLPLLHAFAQPAPAIDGSPFQTKNFQSSVQEAKVGAEHDIPHLDKAL
IVKYAEDIKQLGLL

3D structure

• PDB: 5msv Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.
• Chain: C
• Resolution: 2.34 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PNS	C	S702 N899 H900 Y970 M999 P1013 D1014 R1018 L1131	S30 N225 H226 Y296 M325 P339 D340 R344 L457
BS02	NAP	C	G799 N801 G802 W803 R828 R838 D868 F869 S894 G895 A896 V898 L933 S934 Y970 K974	G125 N127 G128 W129 R154 R164 D194 F195 S220 G221 A222 V224 L259 S260 Y296 K300

Gene Ontology

Molecular Function

• GO:0004467 long-chain fatty acid-CoA ligase activity
• GO:0005524 ATP binding
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0031177 phosphopantetheine binding
• GO:0050661 NADP binding

Biological Process

• GO:0001676 long-chain fatty acid metabolic process
• GO:0006629 lipid metabolic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5msv, PDBe:5msv, PDBj:5msv
• PDBsum: 5msv
• PubMed: 28719588
• UniProt: E5XP76|CAR_SEGRC Carboxylic acid reductase (Gene Name=car)