Structure of PDB 5mq0 Chain C

Receptor sequence
>5mq0C (length=874) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
EVEVLMETKNTQSPQTPLVEPVTERTKLQEHTIFTQLKKNIPKTRYNRDY
MLSMANIPERIINVGVIGPLHSGKTSLMDLLVIDSHKRIPDMSKNVELGW
KPLRYLDNLKQEIDRGLSIKLNGSTLLCTDLESKSRMINFLDAPGHVNFM
DETAVALAASDLVLIVIDVVEGVTFVVEQLIKQSIKNNVAMCFVINKLDR
LILDLKLPPMDAYLKLNHIIANINSFTKGNVFSPIDNNIIFASTKLGFTF
TIKEFVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFENVEKYPT
FVEFILIPLYKIFSYALSMEKDKLKNLLRSNFRVNLSQEALQYDPQPFLK
HVLQLIFRQQTGLVDAITRCYQPFELFDNKTAHLSIPGKSTPEGTLWAHV
LKTVDYGGAEWSLVRIYSGLLKRGDTVRILDTSQSESRQKRQLDETPSCE
VEEIGLLGGRYVYPVHEAHKGQIVLIKGISSAYIKSATLYSVKSKEDMKQ
LKFFKPLDYITEAVFKIVLQPLLPRELPKLLDALNKISKYYPGVIIKVEE
SGEHVILGNGELYMDCLLYDLRASYAKIEIKISDPLTVFSESCSNESFAS
IPVSNISVAAEPMDSKMIQDLSRPRKLSKILRTEYGWDSLASRNVWSFYN
LINDTLPDEISPELLSKYKEQIIQGFYWAVKEGPLAEEPIYGVQYKLLSI
SVPSDVNIDVMKSQIIPLMKKACYVGLLTAIPILLEPIYEVDITVHAPLL
PIVEELMKKRRGSRIYKTIKVAGTPLLEVRGQVPVIESAGFETDLRLSTN
GLGMCQLYFWHKIWRKVPGDVLDKDAFIPKLKPAPINSLSRDFVMKTRRR
KGISTGGFMSNDGPTLEKYISAEL
3D structure
PDB5mq0 Structure of a spliceosome remodelled for exon ligation.
ChainC
Resolution4.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C E102 H103 Q108 K110 R160 P162 D163 N167 K173 R176 I185 R401 E30 H31 Q36 K38 R88 P90 D91 N95 K101 R104 I113 R329
BS02 GTP C L142 H143 G145 K146 T147 S148 L189 S190 G217 K269 R272 S315 T316 K317 L70 H71 G73 K74 T75 S76 L117 S118 G145 K197 R200 S243 T244 K245
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000349 generation of catalytic spliceosome for first transesterification step
GO:0000387 spliceosomal snRNP assembly
GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mq0, PDBe:5mq0, PDBj:5mq0
PDBsum5mq0
PubMed28076345
UniProtP36048|SN114_YEAST Pre-mRNA-splicing factor SNU114 (Gene Name=SNU114)

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