Structure of PDB 5mk0 Chain C

Receptor sequence
>5mk0C (length=359) Species: 9606 (Homo sapiens) [Search protein sequence]
AVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLR
QNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSG
KSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAG
AFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFL
VARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVA
HLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTM
DVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVT
GPDIFAKLV
3D structure
PDB5mk0 Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
ChainC
Resolution1.765 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C D348 P354 K359 D346 P352 K357
BS02 peptide C E137 K141 T145 K192 R198 K199 L202 L338 E135 K139 T143 K190 R196 K197 L200 L336
Gene Ontology
Biological Process
GO:0071985 multivesicular body sorting pathway

View graph for
Biological Process
External links
PDB RCSB:5mk0, PDBe:5mk0, PDBj:5mk0
PDBsum5mk0
PubMed28602823
UniProtQ9H3S7|PTN23_HUMAN Tyrosine-protein phosphatase non-receptor type 23 (Gene Name=PTPN23)

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