Structure of PDB 5mat Chain C

Receptor sequence
>5matC (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
HMERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSYDNLE
KYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDK
GLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSW
MKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLL
VMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMD
FDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQS
3D structure
PDB5mat Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.
ChainC
Resolution2.069 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C195 C200 C221 C137 C142 C163
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5mat, PDBe:5mat, PDBj:5mat
PDBsum5mat
PubMed28135086
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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