Structure of PDB 5lxb Chain C

Receptor sequence
>5lxbC (length=205) Species: 6500 (Aplysia californica) [Search protein sequence]
QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKVDSSTNEVDL
VYWERQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVL
SPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGVTCAVKFGSWVYSGF
EIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVV
KFRER
3D structure
PDB5lxb Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.
ChainC
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7A9 C R55 M114 I116 R55 M114 I116 PDBbind-CN: -logKd/Ki=9.77,Ki=0.17nM
BS02 7A9 C Y91 W145 Y186 C188 C189 Y91 W145 Y186 C188 C189 PDBbind-CN: -logKd/Ki=9.77,Ki=0.17nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5lxb, PDBe:5lxb, PDBj:5lxb
PDBsum5lxb
PubMed27656911
UniProtQ8WSF8

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