Structure of PDB 5lpn Chain C

Receptor sequence
>5lpnC (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
YDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQG
KKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENISKWLR
NIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIETSAKANIN
IEKAFLTLAEDILRKTP
3D structure
PDB5lpn bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.
ChainC
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Q68
Catalytic site (residue number reindexed from 1) Q63
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C T23 T41 T18 T36
BS02 GNP C S18 G19 V20 G21 K22 T23 C24 F34 T36 F38 T41 G67 N122 K123 D125 M126 A153 K154 S13 G14 V15 G16 K17 T18 C19 F29 T31 F33 T36 G62 N117 K118 D120 M121 A145 K146
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:5lpn, PDBe:5lpn, PDBj:5lpn
PDBsum5lpn
PubMed27552051
UniProtP61026|RAB10_HUMAN Ras-related protein Rab-10 (Gene Name=RAB10)

[Back to BioLiP]