Structure of PDB 5lli Chain C

Receptor sequence
>5lliC (length=142) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKER
CLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQ
3D structure
PDB5lli Potent and selective chemical probe of hypoxic signalling downstream of HIF-alpha hydroxylation via VHL inhibition.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6Z3 C W88 Y98 I109 H110 S111 Y112 H115 W117 W27 Y37 I48 H49 S50 Y51 H54 W56 MOAD: Kd=90nM
PDBbind-CN: -logKd/Ki=7.05,Kd=90nM
BindingDB: Kd=90nM,IC50=88nM
External links
PDB RCSB:5lli, PDBe:5lli, PDBj:5lli
PDBsum5lli
PubMed27811928
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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