Structure of PDB 5kyk Chain C

Receptor sequence
>5kykC (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPDSYRKQVVIDGETCL
LDILDTAGQESAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVK
DSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDD
AFYTLVREIRKHKE
3D structure
PDB5kyk Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
ChainC
Resolution2.702 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6ZD C C12 G13 G15 A18 F28 D30 P34 A59 N116 K117 D119 S145 A146 K147 C13 G14 G16 A19 F29 D31 P35 A57 N112 K113 D115 S141 A142 K143
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kyk, PDBe:5kyk, PDBj:5kyk
PDBsum5kyk
PubMed28105276
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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