Structure of PDB 5kq5 Chain C

Receptor sequence
>5kq5C (length=281) Species: 10116 (Rattus norvegicus) [Search protein sequence]
YTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSK
KQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKP
LVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKL
FITMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKG
RVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRLKCYLHETLEAIINRL
VEAEVHRLVVVDEHDVVKGIVSLSDILQALV
3D structure
PDB5kq5 Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
ChainC
Resolution3.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0043531 ADP binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0010628 positive regulation of gene expression
GO:0031669 cellular response to nutrient levels
GO:0051170 import into nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031588 nucleotide-activated protein kinase complex
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kq5, PDBe:5kq5, PDBj:5kq5
PDBsum5kq5
PubMed27490827
UniProtP80385|AAKG1_RAT 5'-AMP-activated protein kinase subunit gamma-1 (Gene Name=Prkag1)

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