Structure of PDB 5k4w Chain C

Receptor sequence

>5k4wC (length=321) Species: 5691 (Trypanosoma brucei) [Search protein sequence]

HMPRVLVTGALGQIGTDLSLALRDKFGADSVLVSDVVEPGAKHPLAGLKG
VEKLDCLDSNGFEKLVKEFKPTWMYHLPAIMSVRGEAEPDLAMDINVNTT
RYALELARKYNIRIFIPSTIAAFGDKCGKTMTKDDTIMNPSTVYGVTKVY
TELLGTWYRQKYGVDFRSVRLPGIISAATLPGGGATDYAIHMYHSALLQK
KCVCPVLPYESLPMMYMPDTLNSLVKIMEAPLEKLTRTVYNITGFSFSPS
ELRFSIERCTDRTIEVEYVEGPAQKIANSWPDSLDDSNARNDWGHQVKYD
IDMMSEDMLRQIPILHGLPSL

3D structure

PDB

5k4w Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.

Chain

Resolution

1.72 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.103: L-threonine 3-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAI	C	G1009 G1012 Q1013 I1014 D1035 V1036 D1055 C1056 L1077 P1078 A1079 M1081 P1117 Y1144 K1148 L1171 I1174	G9 G12 Q13 I14 D35 V36 D55 C56 L77 P78 A79 M81 P117 Y144 K148 L171 I174
BS02	THR	C	M1081 S1082 T1119 Y1144 G1184 A1185 T1186 W1280	M81 S82 T119 Y144 G184 A185 T186 W280

External links

PDB	RCSB:5k4w, PDBe:5k4w, PDBj:5k4w
PDBsum	5k4w
PubMed	30198897
UniProt	Q7YW97

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