Structure of PDB 5k1a Chain C

Receptor sequence
>5k1aC (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
LVNFGNTCYCNSVLQALYFCRPFREKVLAYSLLTCLADLFHSIATIPPKK
FITRLRKAHEFLNYLLNTIADILQEERKQPTWVHEIFQGTLTNETRCLTC
ETISSKDEDFLDLSVDVTSITHCLRGFSNTETLCSEYKYYCEECRSKQEA
HKRMKVKKLPMILALHLVFPLELRLFDRMYDLVAVVVHCGSGPNRGHYIA
IVKSHDFWLLFDDDIVEKIDAQAISESGYILFYQSR
3D structure
PDB5k1a Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N43 C48 H317 D332
Catalytic site (residue number reindexed from 1) N3 C8 H197 D212
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C186 C189 C233 C236 C97 C100 C141 C144
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5k1a, PDBe:5k1a, PDBj:5k1a
PDBsum5k1a
PubMed27373336
UniProtO75317|UBP12_HUMAN Ubiquitin carboxyl-terminal hydrolase 12 (Gene Name=USP12)

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