Structure of PDB 5jy3 Chain C

Receptor sequence
>5jy3C (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPPQSRDARQQRFAHFT
ELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNH
ETECITFLFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLI
AINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK
LVSLRTLSSVHSEQVFALRLKLPPLLSEIWD
3D structure
PDB5jy3 Discovery of Highly Potent Liver X Receptor beta Agonists.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6OX C F271 L274 A275 S278 M312 L313 E315 R319 F329 L330 F340 I353 F49 L52 A53 S56 M90 L91 E93 R97 F107 L108 F116 I129 MOAD: Ki=12nM
BindingDB: EC50=11.0nM,Ki=12nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5jy3, PDBe:5jy3, PDBj:5jy3
PDBsum5jy3
PubMed27994765
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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