Structure of PDB 5jhq Chain C

Receptor sequence
>5jhqC (length=461) Species: 9606 (Homo sapiens) [Search protein sequence]
ALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDV
VEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNW
NYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLT
GEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR
VRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAM
DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELR
ERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVA
SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG
AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMG
NEAVQQILSES
3D structure
PDB5jhq Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R215 S217 F222 G225 F226 L250 N255 S258 F259 H261 D279 W281 Y283 E288 R34 S36 F41 G44 F45 L69 N74 S77 F78 H80 D98 W100 Y102 E107
BS02 peptide C R368 S370 L375 G378 Y379 N408 Y412 H414 F436 E441 R187 S189 L194 G197 Y198 N227 Y231 H233 F255 E260
External links
PDB RCSB:5jhq, PDBe:5jhq, PDBj:5jhq
PDBsum5jhq
PubMed27594684
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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