Structure of PDB 5jdc Chain C

Receptor sequence
>5jdcC (length=239) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKE
RSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTP
LVKTVETQVAELIGTNAIAPFLLTMSFAQRQNLSIVNLCDAMVDQPCMAF
SLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLPEEKDKWRRKVPL
GRRSAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA
3D structure
PDB5jdc Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.
ChainC
Resolution1.78 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R14 D161 Y174 K178
Catalytic site (residue number reindexed from 1) R13 D140 Y153 K157
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C G10 R14 I15 Y34 H35 N36 S37 D62 L63 N93 A94 S95 T126 L159 D161 K178 V206 S207 G9 R13 I14 Y33 H34 N35 S36 D61 L62 N92 A93 S94 T115 L138 D140 K157 V185 S186
BS02 6JP C F97 D161 M163 C168 L209 P210 F96 D140 M142 C147 L187 P188 MOAD: ic50=104.2uM
PDBbind-CN: -logKd/Ki=3.98,IC50=104.2uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0047040 pteridine reductase activity

View graph for
Molecular Function
External links
PDB RCSB:5jdc, PDBe:5jdc, PDBj:5jdc
PDBsum5jdc
PubMed27411733
UniProtO76290

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