Structure of PDB 5j1v Chain C

Receptor sequence
>5j1vC (length=314) Species: 9606 (Homo sapiens) [Search protein sequence]
SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN
VDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLG
LSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENIL
FVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVHYRAP
EVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPL
PKHMIQKTRKRKYCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLR
EALKHPFFDLLKKS
3D structure
PDB5j1v Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.
ChainC
Resolution2.52 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D288 K290 N293 D325
Catalytic site (residue number reindexed from 1) D143 K145 N148 D180
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6FD C L167 V175 A189 K191 F241 E242 L244 L295 L22 V30 A44 K46 F96 E97 L99 L150 BindingDB: IC50=41nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5j1v, PDBe:5j1v, PDBj:5j1v
PDBsum5j1v
PubMed27128181
UniProtP49759|CLK1_HUMAN Dual specificity protein kinase CLK1 (Gene Name=CLK1)

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