Structure of PDB 5iqd Chain C

Receptor sequence
>5iqdC (length=292) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
ATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFKGY
AKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIY
STMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRE
TIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNR
LTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKA
KEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD
3D structure
PDB5iqd Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia.
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP C I208 I224 K226 Y237 Y274 I277 F281 H379 I392 D393 I26 I42 K44 Y50 Y87 I90 F94 H192 I205 D206
BS02 RIO C D374 S376 Y408 E411 E415 E416 E445 Y448 E451 D187 S189 Y221 E224 E228 E229 E258 Y261 E264
BS03 MG C H379 D393 H192 D206
External links
PDB RCSB:5iqd, PDBe:5iqd, PDBj:5iqd
PDBsum5iqd
PubMed27161980
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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