Structure of PDB 5icr Chain C

Receptor sequence
>5icrC (length=618) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
FIKDQIKFPDGSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWA
QFSARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPL
FDPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPRVI
AVDAVPDDVASTWVNPDEPDETTIAYLQYTSRIPTGVQITHLNLATNVVQ
VIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRP
ERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAV
LNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEE
PKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESAT
ELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATD
DATWVRTGDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASKA
IRTGYVAAFSVPANQLPDEVFENAHSGIKRDPDDTSEQLVIVAERAPGKL
DIGPITDDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYL
DGSLRAGKVANDFPDATD
3D structure
PDB5icr 2.25 Angstrom Resolution Crystal Structure of Fatty-Acid-CoA Ligase (FadD32) from Mycobacterium smegmatis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine.
ChainC
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N207 H231 A346
Catalytic site (residue number reindexed from 1) N197 H221 A336
Enzyme Commision number 6.2.1.20: long-chain-fatty-acid--[acyl-carrier-protein] ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 649 C L215 D232 M233 T237 L311 S314 E315 P316 S342 Y343 G344 L345 A346 L350 D469 I480 R483 K601 L205 D222 M223 T227 L301 S304 E305 P306 S332 Y333 G334 L335 A336 L340 D459 I470 R473 K589
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008922 long-chain fatty acid [acyl-carrier-protein] ligase activity
GO:0016874 ligase activity
GO:0070566 adenylyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008610 lipid biosynthetic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5icr, PDBe:5icr, PDBj:5icr
PDBsum5icr
PubMed
UniProtA0R618|FAA32_MYCS2 Long-chain-fatty-acid--AMP ligase FadD32 (Gene Name=fadD32)

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