Structure of PDB 5huy Chain C

Receptor sequence

>5huyC (length=423) Species: 10090 (Mus musculus) [Search protein sequence]

NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYFS

3D structure

PDB

5huy Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits.

Chain

Resolution

1.979 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	R315 N319 V321 G323 E354 W357 N361 E396 W399 S406	R241 N245 V247 G249 E280 W283 N287 E322 W325 S332
BS02	peptide	C	S105 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 N228 W231 S234 N235 R238 Y277	S31 W68 N72 S75 G76 T81 Q107 W110 N114 G117 D118 N154 W157 S160 N161 R164 Y203

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0061608	nuclear import signal receptor activity
GO:0140297	DNA-binding transcription factor binding

	Biological Process
GO:0006606	protein import into nucleus
GO:0015031	protein transport
GO:0075506	entry of viral genome into host nucleus through nuclear pore complex via importin
GO:0099527	postsynapse to nucleus signaling pathway
GO:1903902	positive regulation of viral life cycle

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule
GO:0014069	postsynaptic density
GO:0042564	NLS-dependent protein nuclear import complex
GO:0043657	host cell
GO:0098978	glutamatergic synapse

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5huy, PDBe:5huy, PDBj:5huy
PDBsum	5huy
PubMed	27033706
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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