Structure of PDB 5huw Chain C

Receptor sequence

>5huwC (length=423) Species: 10090 (Mus musculus) [Search protein sequence]

NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYFS

3D structure

PDB

5huw Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits.

Chain

Resolution

1.95 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	S105 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 N228 W231 R238 N239 W273 Y277	S31 W68 N72 S75 G76 T81 Q107 W110 N114 G117 D118 N154 W157 R164 N165 W199 Y203
BS02	peptide	C	G281 V321 T322 G323 W357 N361 A364 W399 S406 G407	G207 V247 T248 G249 W283 N287 A290 W325 S332 G333

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0061608	nuclear import signal receptor activity
GO:0140297	DNA-binding transcription factor binding

	Biological Process
GO:0006606	protein import into nucleus
GO:0015031	protein transport
GO:0075506	entry of viral genome into host nucleus through nuclear pore complex via importin
GO:0099527	postsynapse to nucleus signaling pathway
GO:1903902	positive regulation of viral life cycle

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule
GO:0014069	postsynaptic density
GO:0042564	NLS-dependent protein nuclear import complex
GO:0043657	host cell
GO:0098978	glutamatergic synapse

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5huw, PDBe:5huw, PDBj:5huw
PDBsum	5huw
PubMed	27033706
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

[Back to BioLiP]