Structure of PDB 5hn7 Chain C

Receptor sequence
>5hn7C (length=357) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
LAFFRNMYDKYRDAFLSHLNYSLEEEIKEHISKYYKLLFDYNCLGGKNNR
GILVILIYEYVKNRDINSSEWEKAACLAWCIEILQAAFLVADDIMDKGEM
RRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATF
RDATLKTIIGQHLDTNIFSDKYSDAHREIDVNNINPEQPVIDINMINFGV
YKNIVIHKTAYYSFFLPIVCGMLLAGIDNLIYKKIEDISMLMGEYFQIHD
DYLDIFGDSTKTGKVSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNN
LACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYL
LEILFTG
3D structure
PDB5hn7 Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
ChainC
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K81 A121 D126 D130 R135 D198 K243 F283 D287 D288
Catalytic site (residue number reindexed from 1) K47 A87 D92 D96 R101 D164 K208 F246 D250 D251
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 04M C N154 L157 N120 L123 MOAD: ic50=120uM
BS02 04M C K81 R84 Q119 F122 R136 Q195 T244 Y247 F283 D287 K301 K47 R50 Q85 F88 R102 Q161 T209 Y212 F246 D250 K264 MOAD: ic50=120uM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hn7, PDBe:5hn7, PDBj:5hn7
PDBsum5hn7
PubMed27564465
UniProtA5K4U6

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