Structure of PDB 5hez Chain C

Receptor sequence
>5hezC (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH
LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYL
QKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVK
IGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFG
VVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRP
DGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
3D structure
PDB5hez Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
ChainC
Resolution2.66 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D976 A978 R980 N981 D994 S1016
Catalytic site (residue number reindexed from 1) D135 A137 R139 N140 D153 S175
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1M3 C L1082 K1083 L241 K242 BindingDB: IC50=6.0nM
BS02 ZN C H886 H891 H45 H50
BS03 1M3 C L855 G856 G858 V863 A880 M929 Y931 L932 G935 L983 D994 L14 G15 G17 V22 A39 M88 Y90 L91 G94 L142 D153 BindingDB: IC50=6.0nM
BS04 1M3 C F1019 W1020 Y1021 L1026 W1038 L1078 L1081 G1086 F178 W179 Y180 L185 W197 L237 L240 G245 BindingDB: IC50=6.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5hez, PDBe:5hez, PDBj:5hez
PDBsum5hez
PubMed27807284
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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