Structure of PDB 5h2w Chain C

Receptor sequence

>5h2wC (length=414) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

LPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEF
MRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVE
VKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWT
LSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGP
QEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVI
NAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPL
VKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLE
IADNRIIEVTLDALENILKMGEADKNENADFIEKAGGMEKIFNCQQNEND
KIYEKAYKIIETYF

3D structure

PDB

5h2w Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	L115 S116 R117 E118 W153 N157 S160 G161 T162 T166 E188 Q192 W195 N199 G202 D203 W237 N241 R244 K247 V327 G329 K359 E360 W363 N367 E402 W405	L27 S28 R29 E30 W65 N69 S72 G73 T74 T78 E100 Q104 W107 N111 G114 D115 W149 N153 R156 K159 V239 G241 K271 E272 W275 N279 E314 W317

External links

PDB	RCSB:5h2w, PDBe:5h2w, PDBj:5h2w
PDBsum	5h2w
PubMed	27939291
UniProt	Q02821\|IMA1_YEAST Importin subunit alpha (Gene Name=SRP1)

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