Structure of PDB 5gp1 Chain C

Receptor sequence
>5gp1C (length=261) Species: 64320 (Zika virus) [Search protein sequence]
TGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGH
AVSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGY
TKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSS
PEVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYG
GGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKY
EEDVNLGSGTR
3D structure
PDB5gp1 Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design
ChainC
Resolution2.444 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 GTA C K13 L16 N17 M19 F24 K28 S150 S151 S152 S215 T216 K10 L13 N14 M16 F21 K25 S147 S148 S149 S212 T213
BS02 SAH C S56 G58 G81 C82 T104 K105 H110 E111 V130 D131 V132 F133 D146 I147 S53 G55 G78 C79 T101 K102 H107 E108 V127 D128 V129 F130 D143 I144
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function

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Biological Process
External links
PDB RCSB:5gp1, PDBe:5gp1, PDBj:5gp1
PDBsum5gp1
PubMed27866982
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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