Structure of PDB 5goz Chain C

Receptor sequence
>5gozC (length=261) Species: 64320 (Zika virus) [Search protein sequence]
TGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGH
AVSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGY
TKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSS
PEVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYG
GGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKY
EEDVNLGSGTR
3D structure
PDB5goz Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design
ChainC
Resolution2.049 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP C K13 N17 M19 F24 K28 S151 S152 S215 K10 N14 M16 F21 K25 S148 S149 S212
BS02 GTP C E149 S153 E155 V156 E146 S150 E152 V153
BS03 SAH C S56 G81 G86 W87 T104 K105 H110 V132 F133 D146 S53 G78 G83 W84 T101 K102 H107 V129 F130 D143
BS04 POP C R41 S56 R57 R84 R38 S53 R54 R81
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5goz, PDBe:5goz, PDBj:5goz
PDBsum5goz
PubMed27866982
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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