Structure of PDB 5fye Chain C

Receptor sequence
>5fyeC (length=296) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
HHHHKRKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAG
IREILIISTPQDTPRFQQLLGDGSNWGLDLQYAVQPSPDGLAQAFLIGES
FIGNDLSALVLGDNLYYGHDFHELLGSASQRQTGASVFAYHVLDPERYGV
VEFDQGGKAISLEEKPLEPKSNYAVTGLYFYDQQVVDIARDLKPSPRGEL
EITDVNRAYLERGQLSVEIMGRGYAWLDTGTHDSLLEAGQFIATLENRQG
LKVACPEEIAYRQKWIDAAQLEKLAAPLAKNGYGQYLKRLLTETVY
3D structure
PDB5fye Allosteric Competitive Inhibitors of the Glucose-1-Phosphate Thymidylyltransferase (Rmla) from Pseudomonas Aeruginosa.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.24: glucose-1-phosphate thymidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LD6 C S41 L45 Y113 Y114 G115 H119 V250 A251 E255 R259 S44 L48 Y116 Y117 G118 H122 V253 A254 E258 R262
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008879 glucose-1-phosphate thymidylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0009244 lipopolysaccharide core region biosynthetic process
GO:0019305 dTDP-rhamnose biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5fye, PDBe:5fye, PDBj:5fye
PDBsum5fye
PubMed
UniProtQ9HU22

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